Correlation of serum B lymphocyte stimulator and β2 microglobulin with autoantibody secretion and systemic involvement in primary Sjögren’s syndrome
Identifieur interne : 000349 ( France/Analysis ); précédent : 000348; suivant : 000350Correlation of serum B lymphocyte stimulator and β2 microglobulin with autoantibody secretion and systemic involvement in primary Sjögren’s syndrome
Auteurs : J-E Gottenberg [France] ; M. Busson [France] ; J. Cohen-Solal [France] ; F. Lavie [France] ; K. Abbed ; R P Kimberly [États-Unis] ; J. Sibilia [France] ; X. Mariette [France]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2005-07.
English descriptors
- KwdEn :
- Teeft :
- Arthritis rheum, Autoantibody, Autoantibody production, Autoantibody secretion, Bicetre, Blys, Blys levels, Bronchiolar involvement, Cell activation, Disease activity, Erythrocyte sedimentation rate, Extraglandular, Extraglandular involvement, Gamma globulin, Hopital, Hydroxychloroquine, Hydroxychloroquine treatment, Kremlin bicetre, Lymphocyte, Lymphocyte stimulator, Lymphoma, Major histocompatibility, Microglobulin, Microglobulin concentration, Microglobulin level, Microglobulin levels, Microglobulin value, Multivariate, Multivariate analysis, Neurological involvement, Positive results, Primary syndrome, Reactive, Reactive protein, Reactive protein level, Rheum, Rheumatoid, Rheumatoid factor, Serial determinations, Serum, Serum blys, Serum concentrations, Stimulator, Syndrome, Systemic involvement, Systemic lupus erythematosus, Univariate, Univariate analysis.
Abstract
Background: In primary Sjögren’s syndrome (pSS), extraglandular involvement might result from more intense stimulation of autoreactive B cells. Thus markers of B cell activation could be useful in the clinical assessment of this disease. Objective: To investigate the association of serum B lymphocyte stimulator (BLyS) and β2 microglobulin with autoantibody production and extraglandular involvement in pSS. Methods: Serum concentrations of BLyS and β2 microglobulin were analysed in 177 patients with pSS according to the American–European consensus group criteria. Serum β2 microglobulin was determined serially in 25 patients. Results: Autoantibody secretion (presence of anti-SSA antibody alone or of both anti-SSA and anti-SSB) was associated with increased serum BLyS and β2 microglobulin. No correlation was found between BLyS and β2 microglobulin levels (p = 0.36). Serum concentrations of β2 microglobulin and C reactive protein and positive anti-SSB antibody results were associated with extraglandular involvement on univariate analysis (p<10−4, p = 0.003, and p = 0.004, respectively). Serum β2 microglobulin was also significantly increased in patients with extraglandular involvement without autoantibodies (mean (SD): 1.75 (0.7) v 1.39 (0.5) mg/l, p = 0.039). Multivariate analysis showed that extraglandular involvement was associated only with increased serum β2 microglobulin (p = 0.035, odds ratio = 2.78 (95% confidence interval, 1.07 to 7.22)). Among the 25 patients who had serial determinations of serum β2 microglobulin, the concentrations were increased in all those with disease flare and decreased in three following treatment. Serum BLyS, gamma globulin, IgG, and rheumatoid factor levels were not associated with features of systemic involvement. Conclusions: Serum β2 microglobulin and BLyS reflect B cell activation in different ways in pSS. Serum β2 microglobulin assessment could be helpful as an activity marker in pSS.
Url:
DOI: 10.1136/ard.2004.030643
Affiliations:
- France, États-Unis
- Alabama, Alsace (région administrative), Grand Est, Île-de-France
- Paris, Strasbourg
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ISTEX:09EF1A5FE6EEE42F7CC060AD8734A806E9491908Le document en format XML
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Abbed</name><affiliation><wicri:noCountry code="subField">Bicêtre</wicri:noCountry></affiliation></author><author><name sortKey="Kimberly, R P" sort="Kimberly, R P" uniqKey="Kimberly R" first="R P" last="Kimberly">R P Kimberly</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, Alabama</wicri:regionArea><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Sibilia, J" sort="Sibilia, J" uniqKey="Sibilia J" first="J" last="Sibilia">J. Sibilia</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Rhumatologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Mariette, X" sort="Mariette, X" uniqKey="Mariette X" first="X" last="Mariette">X. Mariette</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Rhumatologie, INSERM EMI 109, Bicêtre Hospital, Le Kremlin Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the Rheumatic Diseases</title><title level="j" type="abbrev">Ann Rheum Dis</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><publisher>BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><date type="published" when="2005-07">2005-07</date><biblScope unit="volume">64</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1050">1050</biblScope></imprint><idno type="ISSN">0003-4967</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0003-4967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BLyS</term><term>BLyS, B lymphocyte stimulator</term><term>PSS, primary Sjögren’s syndrome</term><term>SJC, swollen joint count</term><term>SSA/SSB, Sjögren’s syndrome antigen A or B</term><term>anti-SSA/SSB</term><term>primary Sjögren’s syndrome</term><term>β2 microglobulin</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Arthritis rheum</term><term>Autoantibody</term><term>Autoantibody production</term><term>Autoantibody secretion</term><term>Bicetre</term><term>Blys</term><term>Blys levels</term><term>Bronchiolar involvement</term><term>Cell activation</term><term>Disease activity</term><term>Erythrocyte sedimentation rate</term><term>Extraglandular</term><term>Extraglandular involvement</term><term>Gamma globulin</term><term>Hopital</term><term>Hydroxychloroquine</term><term>Hydroxychloroquine treatment</term><term>Kremlin bicetre</term><term>Lymphocyte</term><term>Lymphocyte stimulator</term><term>Lymphoma</term><term>Major histocompatibility</term><term>Microglobulin</term><term>Microglobulin concentration</term><term>Microglobulin level</term><term>Microglobulin levels</term><term>Microglobulin value</term><term>Multivariate</term><term>Multivariate analysis</term><term>Neurological involvement</term><term>Positive results</term><term>Primary syndrome</term><term>Reactive</term><term>Reactive protein</term><term>Reactive protein level</term><term>Rheum</term><term>Rheumatoid</term><term>Rheumatoid factor</term><term>Serial determinations</term><term>Serum</term><term>Serum blys</term><term>Serum concentrations</term><term>Stimulator</term><term>Syndrome</term><term>Systemic involvement</term><term>Systemic lupus erythematosus</term><term>Univariate</term><term>Univariate analysis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: In primary Sjögren’s syndrome (pSS), extraglandular involvement might result from more intense stimulation of autoreactive B cells. Thus markers of B cell activation could be useful in the clinical assessment of this disease. Objective: To investigate the association of serum B lymphocyte stimulator (BLyS) and β2 microglobulin with autoantibody production and extraglandular involvement in pSS. Methods: Serum concentrations of BLyS and β2 microglobulin were analysed in 177 patients with pSS according to the American–European consensus group criteria. Serum β2 microglobulin was determined serially in 25 patients. Results: Autoantibody secretion (presence of anti-SSA antibody alone or of both anti-SSA and anti-SSB) was associated with increased serum BLyS and β2 microglobulin. No correlation was found between BLyS and β2 microglobulin levels (p = 0.36). Serum concentrations of β2 microglobulin and C reactive protein and positive anti-SSB antibody results were associated with extraglandular involvement on univariate analysis (p<10−4, p = 0.003, and p = 0.004, respectively). Serum β2 microglobulin was also significantly increased in patients with extraglandular involvement without autoantibodies (mean (SD): 1.75 (0.7) v 1.39 (0.5) mg/l, p = 0.039). Multivariate analysis showed that extraglandular involvement was associated only with increased serum β2 microglobulin (p = 0.035, odds ratio = 2.78 (95% confidence interval, 1.07 to 7.22)). Among the 25 patients who had serial determinations of serum β2 microglobulin, the concentrations were increased in all those with disease flare and decreased in three following treatment. Serum BLyS, gamma globulin, IgG, and rheumatoid factor levels were not associated with features of systemic involvement. Conclusions: Serum β2 microglobulin and BLyS reflect B cell activation in different ways in pSS. Serum β2 microglobulin assessment could be helpful as an activity marker in pSS.</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Alabama</li><li>Alsace (région administrative)</li><li>Grand Est</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Strasbourg</li></settlement></list><tree><noCountry><name sortKey="Abbed, K" sort="Abbed, K" uniqKey="Abbed K" first="K" last="Abbed">K. Abbed</name></noCountry><country name="France"><noRegion><name sortKey="Gottenberg, J E" sort="Gottenberg, J E" uniqKey="Gottenberg J" first="J-E" last="Gottenberg">J-E Gottenberg</name></noRegion><name sortKey="Busson, M" sort="Busson, M" uniqKey="Busson M" first="M" last="Busson">M. Busson</name><name sortKey="Cohen Solal, J" sort="Cohen Solal, J" uniqKey="Cohen Solal J" first="J" last="Cohen-Solal">J. Cohen-Solal</name><name sortKey="Lavie, F" sort="Lavie, F" uniqKey="Lavie F" first="F" last="Lavie">F. Lavie</name><name sortKey="Mariette, X" sort="Mariette, X" uniqKey="Mariette X" first="X" last="Mariette">X. Mariette</name><name sortKey="Sibilia, J" sort="Sibilia, J" uniqKey="Sibilia J" first="J" last="Sibilia">J. Sibilia</name></country><country name="États-Unis"><region name="Alabama"><name sortKey="Kimberly, R P" sort="Kimberly, R P" uniqKey="Kimberly R" first="R P" last="Kimberly">R P Kimberly</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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